Background
Wound therapeutic is a fancy physiological course of that may be compromised by an infection and impaired tissue regeneration. Standard dressings, sometimes made out of pure fibers comparable to cotton or linen, supply restricted performance. Nanofiber scaffolds, significantly these primarily based on biocompatible polymers like PLA, present excessive floor space and porosity, making them appropriate for managed drug supply and tissue interplay.
Curcumin, a bioactive compound derived from turmeric, has demonstrated anti-inflammatory and antibacterial properties. Nevertheless, its use in wound care is proscribed by poor solubility and low bioavailability. CNTs supply complementary benefits: they possess intrinsic antibacterial exercise and might enhance the mechanical properties and drug launch profiles of polymer-based methods.
This examine investigates the combination of CNTs into PLA-curcumin nanofibers to create a multifunctional wound dressing able to each structural help and an infection management.
The Present Examine
The dressing was produced utilizing electrospinning, a way appropriate for fabricating nanofibers with managed morphology. PLA (molecular weight: 203,000 g/mol) was dissolved in dichloromethane, adopted by the addition of curcumin to make sure uniform dispersion. CNTs had been integrated at various concentrations to evaluate their results on the fabric’s structural and practical properties.
Electrospun nanofibers had been collected utilizing an ordinary setup with a managed circulation fee and glued needle-to-collector distance. Characterization included Fourier-transform infrared spectroscopy (FTIR) for chemical evaluation and scanning electron microscopy (SEM) for morphology. Tensile exams evaluated mechanical energy, whereas curcumin launch profiles had been analyzed by way of in vitro assays. Antibacterial efficiency was assessed utilizing customary strains of Staphylococcus aureus and Escherichia coli.
Outcomes and Dialogue
Incorporating CNTs considerably improved the mechanical energy and thermal stability of the PLA-curcumin nanofibers. Tensile testing confirmed that even small additions of CNTs enhanced tensile energy in comparison with pure PLA. Drug launch research confirmed a managed and sustained launch of curcumin, with the speed modulated by CNT focus. This impact was attributed to adjustments in scaffold porosity and microstructure.
Antibacterial assays revealed that CNT-containing composites had a marked inhibitory impact on bacterial progress. The PLA-Cur-0.05 % CNT formulation confirmed the best antibacterial exercise, with a 78.95 % discount in microbial progress. Whereas curcumin alone confirmed restricted antibacterial efficacy within the PLA matrix, CNTs appeared to help each dispersion and membrane-disruptive mechanisms, contributing to improved outcomes.
Water absorption exams additional supported the composite’s suitability for wound care. Whereas PLA alone exhibited excessive water uptake, the addition of curcumin and CNTs lowered this absorption. A extra average water uptake profile is advantageous for managing exudates with out compromising the mechanical integrity of the dressing.
Conclusion
This examine demonstrates the potential of CNT-enhanced PLA-curcumin nanofiber mats as multifunctional wound dressings. The mix of improved mechanical properties, antibacterial exercise, and managed drug launch gives a promising platform for an infection administration and wound therapeutic help. The design leverages nanostructure engineering to beat the restrictions of typical supplies and drug supply methods.
Future analysis ought to discover in vivo efficiency, scalability, and additional refinement of the composite formulation. Optimizing part ratios and evaluating long-term biocompatibility shall be key steps towards scientific software.
Journal Reference
Faal M., et al. (2025). Fabrication and analysis of polylactic acid-curcumin containing carbon nanotubes (CNTs) wound dressing utilizing electrospinning methodology with experimental and computational approaches. Scientific Experiences. DOI: 10.1038/s41598-025-98393-2, https://www.nature.com/articles/s41598-025-98393-2
